BRCA and Babies
If you or your partner have a BRCA gene mutation your child will have a 50% chance of inheriting it. If both partners carry the same mutation the likelihood increases to 75%. If both parents have BRCA2 their child could have Fanconi anaemia – which can result in abnormalities and increase the risk of childhood cancers.
Currently in the UK, if you are planning your first child, you will be eligible for in vitro fertilisation (IVF) on the NHS. This is a very personal choice.
Pre-implantation genetic diagnosis
PGD is a technique used within IVF when one or both parents carry a genetic mutation. Tests are performed on embryos created outside the body to determine whether they carry a genetic mutation (in this case BRCA1/2). Only unaffected embryos will be transferred to the uterus. The average success rate for this type of IVF is around 33% (Guy’s and St Thomas).
Taking chances?
Many BRCA Mutants don’t go down the IVF route, taking the 50/50 chance – this is completely fine. There is hope for the future with cancer research and the development of new operations to support those with BRCA mutations. Some might feel guilty about passing on a genetic mutation to their children, but remember, there are options for people with BRCA and they can live a wonderful, happy and inspired life.